Granny's Cherokee Casserole

Granny's Cherokee Casserole

Heather Denard 0

"My Granny always made this for Thanksgiving and Christmas dinner."

Ingredients {{adjustedServings}} servings 241 cals

Serving size has been adjusted!

Original recipe yields 11 servings



Amount per serving ({{servings}} total)

  • Calories:
  • 241 kcal
  • 12%
  • Fat:
  • 15.1 g
  • 23%
  • Carbs:
  • 12.8g
  • 4%
  • Protein:
  • 12.4 g
  • 25%
  • Cholesterol:
  • 45 mg
  • 15%
  • Sodium:
  • 522 mg
  • 21%

Based on a 2,000 calorie diet

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  1. Preheat oven to 350 degrees F (175 degrees C).
  2. Place ground beef and onions in a large, deep skillet. Cook over medium high heat until beef is evenly brown. Drain any excess fat.
  3. Add the soup, rice, tomatoes, garlic powder, thyme, oregano and sugar. Mix well and cook over medium heat for 10 minutes. Place in a 9x13 inch casserole dish.
  4. Top with cheese slices and bake for 15 to 20 minutes or until cheese is bubbling and browning.
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Reviews 76

  1. 91 Ratings


This recipe is a great base to add what you would like. I actually changed it up quite a bit. I used real rice that I cooked while I cooked the ground beef and onions and 'minced' garlic. I omitted the oregano, thyme, and sugar. I added a good amount of salt, pepper, and Red pepper flakes ground through a spice grinder very finely. I used a can of rotel tomatoes (milder) and Cream of mushroom with roasted garlic. I blended everything together and added about a cup of milk so it wouldn't dry out in the oven. I topped it with shredded "mexican" cheese and some shredded 5 Cheese italian. Baked it as directed. It was really good. You could do so much with this recipe. My hubby and I were talking about stuffing tortillas with it, toppin them with the cheese and your choice of salsa or enchilada sauce!!


I really like the mix of flavors and texture in this recipe. Very creamy! I altered the recipe a little...Browned ground turkey w/ seasoned salt, italian spice, cumin and paprika, along w/ the onion and some fresh garlic, and then threw in the tomatoes, cooked rice and soup, letting it simmer for a few minutes, before adding shredded cheddar to melt. I did not bake this in the oven; just did it all on the stovetop. It came out great! Very easy and quick, using simple ingredients. Will make again...

Amanda L.

I made this for supper tonite..i made a few changes in the seasonings...i used paprika, garlic powder, salt/pepper and a little bit of chili powder and about 1tbs. of crushed red peppers, also used 1 can of tomatoes with green chilis, this was very husband tasted it and said it was right up his alley, i offered him sour cream to top it off and he said no it was perfect the way it was! Oh yeah, i also used pepperjack and american cheese slices on the top. I will be making this again..Thanks for the recipe!